Hormonal Regulation of Intestinal Nutrient Absorption in Vertebrates

Nutrient Effects on Intestinal Drug Absorption*

The effect of oral co-administration of nutrients on intestinal drug absorption is a function of drug dissolution, gastrointestinal (GI) residence time and intestinal membrane transport. Nutrient effects on GI residence time may influence the availability of the drug for absorption when dissolution is rate controlling; alternatively, nutrient effects on membrane transport pathways may dictate v...

Systemic regulation of intestinal iron absorption.

The intestinal absorption of the essential trace element iron and its mobilization from storage sites in the body are controlled by systemic signals that reflect tissue iron requirements. Recent advances have indicated that the liver-derived peptide hepcidin plays a central role in this process by repressing iron release from intestinal enterocytes, macrophages and other body cells. When iron r...

Regulation of intestinal non-haem iron absorption.

Minireview on Regulation of Intestinal Calcium Absorption

An overview of current information on the mechanisms by which intestinal calcium absorption occurs is described in this article. Both paracellular and transcellular pathways are analyzed. Special emphasis focuses on molecules participating in the latter pathway, such as TRPV5 and TRPV6 channels, located in the apical region of the enterocytes, CB 9k and CB 28k , presumably involved in the catio...

Nutrient and hormonal regulation of pyruvate kinase gene expression.

Mammalian pyruvate kinase (PK), a key glycolytic enzyme, has two genes named PKL and PKM, which produce the L- and R-type isoenzymes by means of alternative promoters, and the M1-and M2-types by mutually exclusive alternative splicing respectively. The expression of these genes is tissue-specific and under developmental, dietary and hormonal control. The L-type isoenzyme (L-PK) gene contains mu...